曾园园

（1）研究方向

1、蛋白翻译后修饰参与非小细胞肺癌化学耐药的机制

2、细胞异常代谢在肺部肿瘤发生发展中的作用及机制

（2）招生专业

临床医学-内科学-呼吸系病学

（3）招生类型

学术型硕士

（4）E-mail

zengyuanyuan0921@163.com

（5）导师简介

曾园园，中共党员、医学博士、副研究员、苏州大学附属第一医院临床医学博士后，入选苏州市科协青年科技人才托举工程。近年来以通讯作者或第一作者在国内外学术期刊上发表论文10余篇。作为项目负责人主持国家自然科学基金面上项目和青年项目各1项，江苏省高校基础科学研究面上项目1项，其他市厅级课题2项。获江苏省科学技术奖一等奖、三等奖等省部级奖4项，市厅级奖2项和苏州市自然科学优秀学术论文奖二等奖2项。荣获苏州大学附属第一医院“白求恩”杯先进个人和院五四青年奖章。

（6）代表性论文

1. Du J, Huang Y, Jing S, Pei Y, Qian Y, Zeng Y. Serine hydroxymethyltransferase 2 predicts unfavorable outcomes in multiple cancer: a systematic review and meta-analysis. Transl Cancer Res. 2022 Mar;11(3):444-455.

2. Xu M, Kong Y, Chen N, Peng W, Zi R, Jiang M, Zhu J, Wang Y, Yue J, Lv J, Zeng Y, Chin YE. Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis. Front Immunol. 2022 Mar 22;13:855645.

3. Zhang R, Zhang W, Zeng Y, Li Y, Zhou J, Zhang Y, Wang A, Lv Y, Zhu J, Liu Z, Huang JA. The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer. Cell Death Discov. 2021 Nov 6;7(1):336.

4. Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer. 2021 Aug 8;12(19):5888-5894.

5. Zhang J, Zeng Y, Xing Y, Li X, Zhou L, Hu L, Chin YE, Wu M. Myristoylation-mediated phase separation of EZH2 compartmentalizes STAT3 to promote lung cancer growth. Cancer Lett. 2021 Sep 28;516:84-98.

6. Du W, Zhu J, Zeng Y, Liu T, Zhang Y, Cai T, Fu Y, Zhang W, Zhang R, Liu Z, Huang JA. KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway. Cell Death Differ. 2021 Apr;28(4):1284-1300.

7. Liu T, Zhu J, Du W, Ning W, Zhang Y, Zeng Y, Liu Z, Huang JA. AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma. Respir Res. 2020 Sep 1;21(1):227.

8. Zhang Y, Zeng Y, Liu T, Du W, Zhu J, Liu Z, Huang JA. The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer. Respir Res. 2019 Jul 22;20(1):164.

9. Ding Z, Zhu J, Zeng Y, Du W, Zhang Y, Tang H, Zheng Y, Qin H, Liu Z, Huang JA. The regulation of Neuropilin 1 expression by miR-338-3p promotes non-small cell lung cancer via changes in EGFR signaling. Mol Carcinog. 2019 Jun;58(6):1019-1032.

10. Zeng Y, Zhu J, Qin H, Shen D, Lei Z, Li W, Ding Z, Huang JA, Liu Z. Methylated +322-327 CpG site decreases hOGG1 mRNA expression in non-small cell lung cancer.Oncol Rep. 2017 Jul;38(1):529-537.