杜雯雯

（1）研究方向

肺部肿瘤的临床与基础研究

（2）招生专业

临床医学-内科学-呼吸系病学

（3）招生类型

学术型硕士

（4）E-mail

daisy910917@163.com

（5）导师简介

杜雯雯，中共党员、医学博士、硕士研究生导师，苏州大学附属第一医院呼吸与危重症医学科主治医师，美国匹兹堡大学访问学者。先后入选江苏省双创博士，苏州市姑苏卫生人才。主持国家自然科学基金青年项目1项，江苏省自然科学基金青年项目1项，市厅级及院内课题各1项。获江苏省医学新技术引进二等奖1项，江苏省医学科技奖三等奖1项和苏州市自然科学优秀学术论文二等奖1项。

（6）代表性论文

1. Lian Z, Pang P, Zhu Y, Du W, Zhou J. Prognostic Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma. Front Oncol. 2022; 12: 832517.

2. Du W, Zhu J, Zeng Y, Liu T, Zhang Y, Cai T, Fu Y, Zhang W, Zhang R, Liu Z, Huang JA. KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway. Cell Death Differ. 2021; 28: 1284-1300.

3. Du W, Liu T, Zhang Y, Zeng Y, Zhu J, Tang H, Liu Z, Huang JA. MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer. J Cancer. 2020; 11(9):2610-2620.

4. Du W, Sun L, Liu T, Zhu J, Zeng Y, Zhang Y, Wang X, Liu Z, Huang JA. The miR-625-3p/AXL axis induces non-T790M acquired resistance to EGFR-TKI via activation of the TGF-β/Smad pathway and EMT in EGFR-mutant non-small cell lung cancer. Oncol Rep. 2020; 44(1):185-195.

5. Du W, Tang H, Lei Z, Zhu J, Zeng Y, Liu Z, Huang JA. miR-335-5p inhibits TGF-β1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1. Respir Res. 2019; 20(1):225.

6. Fu R, Du W, Ding ZL，Wang Yi, Li Y, Zhu JJ，Zeng YY, Zhen YL, Liu Z, Huang JA. HIF-1α promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment. Cell Death Dis, 2021, 12: 394.

7. Lian Z, Du W, Zhang Y, Fu Y, Liu T, Wang A, Cai T, Zhu J, Zeng Y, Liu Z, Huang JA. Anlotinib can overcome acquired resistance to EGFR-TKIs via FGFR1 signaling in non-small cell lung cancer without harboring EGFR T790M mutation. Thorac Cancer. 2020; 11(7):1934-1943.

8. Ding Z, Du W, Lei Z, Zhang Y, Zhu J, Zeng Y, Wang S, Zheng Y, Liu Z, Huang JA. Neuropilin 1 modulates TGF-β1-induced epithelial-mesenchymal transition in non-small cell lung cancer. Int J Oncol. 2020; 56(2):531-543.

9. Ding Z, Zhu J, Zeng Y, Du W, Zhang Y, Tang H, Zheng Y, Qin H, Liu Z, Huang JA. The regulation of Neuropilin 1 expression by miR-338-3p promotes non-small cell lung cancer via changes in EGFR signaling. Mol Carcinog. 2019; 58(6):1019-1032.